Howlader N, Noone AM, Krapcho M, Garshell J, Neyman N, Altekruse SF, et al. The role of genomic profiling in adolescents and young adults (AYAs) with advanced cancer participating in phase I clinical trials. Mcveigh TP, Sundar R, Diamantis N, Kaye SB, Banerji U, Lopez J, et al. The management of adolescents and young adults with cancer.
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Further studies including more samples are essential to investigate whether ASXL1 and KMT2C could be considered as potentially targetable genomic signatures for young patients.ĪSXL1 adolescents and young adults (AYAs) cholangiocarcinoma early-onset mutation.Ĭopyright © 2020 Feng, Tong, Yan, He, Chen and Wang. Conclusion: This study offered a preliminary landscape of the clinical and molecular features of early-onset biliary cancers. Moreover, AYAs were relevant to poor differentiation and advanced tumor stage. And those genes were found to be associated with poorer differentiation, deubiquitination, and WNT signal pathway. Besides ASXL1 and KMT2C, the genes enriched in AYAs with CCA were analyzed by pathway and process enrichment analysis. In this study, AYAs gained an enhanced frequency of additional sex combs like 1 (ASXL1) ( p = 0.02) and KMT2C ( p = 0.02) mutation than their older counterparts. Nevertheless, none of the AYAs had MSI status. Microsatellite instability (MSI) occurred in 3% of older patients in the present study. From the anatomical perspective, more extrahepatic CCA was detected in the AYA group. Specific to patients with stage IV CCAs who underwent chemotherapy, AYAs were associated with significantly poorer overall survival (OS) ( p = 0.03, hazards ratio (HR) 3.01, 95% confidence interval (CI) 1.14-4.91). Results: Compared to older adults, AYAs with CCA presented with worse overall survival, although the difference was not significant. All statistical analyses were performed with GraphPad Prism (version 7.0 GraphPad Software, La Jolla, California) and R studio (version 3.6.1 R studio, Boston, Massachusetts). P < 0.05 was considered statistically significant. Metascape and GEPIA datasets were used for bioinformatic analysis. Pathway and process enrichment analysis had been carried out with the following ontology sources: KEGG Pathway, GO Biological Processes, Reactome Gene Sets, Canonical Pathways, and CORUM. Methods: Three cohorts, including the external dataset (TCGA and MSKCC) and the perihilar CCA databank of Chinese tertiary hospitals, were contained in this study. This study is performed to investigate the clinical and molecular features of AYAs with CCA. However, compared to other solid cancers, relatively few studies have been conducted in this age group in cholangiocarcinoma (CCA). Background: Adolescents and young adults (AYAs) diagnosed with cancer between ages 15 and 45 years may exhibit unique biologic and genomic characteristics as well as clinical features, resulting in differences in clinical characters and drug resistance.
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